| Date | Home | Score | Away | R | Tournament |
|---|---|---|---|---|---|
| 17 Apr 2025 | Pumas UNAM | 2–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 14 Apr 2025 |
Santos Laguna
|
1–2 |
Querétaro
|
A | MEX · Liga MX |
| 07 Apr 2025 |
Deportivo Toluca
|
2–1 |
Santos Laguna
|
H | MEX · Liga MX |
| 31 Mar 2025 |
Santos Laguna
|
2–3 |
Atlético de San Luis
|
A | MEX · Liga MX |
| 15 Mar 2025 |
Tigres UANL
|
3–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 09 Mar 2025 |
Santos Laguna
|
2–1 |
Club León
|
H | MEX · Liga MX |
| 03 Mar 2025 |
CF Monterrey
|
4–2 |
Santos Laguna
|
H | MEX · Liga MX |
| 23 Feb 2025 |
Santos Laguna
|
2–0 |
Atlas
|
H | MEX · Liga MX |
| 20 Feb 2025 |
Santos Laguna
|
0–1 |
Cruz Azul
|
A | MEX · Liga MX |
| 15 Feb 2025 |
Mazatlán
|
1–1 |
Santos Laguna
|
D | MEX · Liga MX |
| 08 Feb 2025 |
Club Necaxa
|
3–2 |
Santos Laguna
|
H | MEX · Liga MX |
| 02 Feb 2025 |
Santos Laguna
|
0–2 |
Club Puebla
|
A | MEX · Liga MX |
| 30 Jan 2025 |
FC Juárez
|
1–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 26 Jan 2025 |
Santos Laguna
|
1–4 |
Club América
|
A | MEX · Liga MX |
| 21 Jan 2025 |
CF Pachuca
|
2–1 |
Santos Laguna
|
H | MEX · Liga MX |
| 12 Jan 2025 |
Guadalajara Chivas
|
1–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 09 Nov 2024 |
Querétaro
|
3–2 |
Santos Laguna
|
H | MEX · Liga MX |
| 06 Nov 2024 |
Santos Laguna
|
0–2 |
Guadalajara Chivas
|
A | MEX · Liga MX |
| 03 Nov 2024 |
Cruz Azul
|
2–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 26 Oct 2024 |
Santos Laguna
|
0–0 |
Mazatlán
|
D | MEX · Liga MX |
| 23 Oct 2024 |
Santos Laguna
|
1–1 |
CF Pachuca
|
D | MEX · Liga MX |
| 20 Oct 2024 |
Club América
|
3–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 07 Oct 2024 |
Santos Laguna
|
0–2 |
FC Juárez
|
A | MEX · Liga MX |
| 29 Sep 2024 |
Atlético de San Luis
|
3–1 |
Santos Laguna
|
H | MEX · Liga MX |
| 23 Sep 2024 |
Santos Laguna
|
2–0 |
Deportivo Toluca
|
H | MEX · Liga MX |
| 15 Sep 2024 |
Santos Laguna
|
0–2 |
CF Monterrey
|
A | MEX · Liga MX |
| 02 Sep 2024 |
Santos Laguna
|
3–2 |
Club Necaxa
|
H | MEX · Liga MX |
| 25 Aug 2024 |
Club León
|
1–1 |
Santos Laguna
|
D | MEX · Liga MX |
| 19 Aug 2024 | Club Tijuana | 3–1 |
Santos Laguna
|
H | MEX · Liga MX |
| 21 Jul 2024 |
Santos Laguna
|
0–3 |
Tigres UANL
|
A | MEX · Liga MX |
| 17 Jul 2024 |
Atlas
|
1–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 14 Jul 2024 |
Santos Laguna
|
1–1 | Pumas UNAM | D | MEX · Liga MX |
| 05 Jul 2024 |
Club Puebla
|
1–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 29 Apr 2024 |
Santos Laguna
|
0–3 |
Atlético de San Luis
|
A | MEX · Liga MX |
| 21 Apr 2024 |
Santos Laguna
|
0–2 |
CF Pachuca
|
A | MEX · Liga MX |
| 13 Apr 2024 |
Club Necaxa
|
2–0 |
Santos Laguna
|
H | MEX · Liga MX |
| 07 Apr 2024 |
Santos Laguna
|
1–1 |
Club América
|
D | MEX · Liga MX |
| 01 Apr 2024 |
FC Juárez
|
2–1 |
Santos Laguna
|
H | MEX · Liga MX |
| 16 Mar 2024 | Club Tijuana | 2–2 |
Santos Laguna
|
D | MEX · Liga MX |
| 10 Mar 2024 |
Santos Laguna
|
3–0 |
Cruz Azul
|
H | MEX · Liga MX |