| 18 Sep 2021 |
Formartine United
|
2–2
|
Cumnock
|
D
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Dunbar United
|
2–0
|
Camelon Juniors
|
H
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Deveronvale
|
2–2
|
Haddington Athletic
|
D
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Coldstream
|
1–10
|
East Kilbride
|
A
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Clydebank
|
7–0
|
Dalkeith Thistle
|
H
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Clachnacuddin
|
1–2
|
Dunipace
|
A
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Caledonian Braves
|
0–1
|
Stirling University
|
A
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
BSC Glasgow
|
6–0
|
Glasgow University
|
H
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Brechin City
|
5–0
|
Vale of Leithen
|
H
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Blackburn United
|
1–2
|
Rothes
|
A
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Banks O'Dee
|
1–0
|
Turriff United
|
H
|
SCO · Scottish Cup
|
| 18 Sep 2021 |
Penicuik Athletic
|
1–3
|
Tranent Juniors
|
A
|
SCO · Scottish Cup
|
| 17 Sep 2021 |
Cumbernauld Colts
|
1–1
|
Buckie Thistle
|
D
|
SCO · Scottish Cup
|
| 17 Sep 2021 |
East Stirlingshire
|
3–0
|
Fort William
|
H
|
SCO · Scottish Cup
|
