| Date | Home | Score | Away | R | Tournament |
|---|---|---|---|---|---|
| 01 May 2022 | Pumas UNAM | 2–0 |
|
H | MEX · Liga MX |
| 24 Apr 2022 |
Guadalajara Chivas
|
3–1 | Pumas UNAM | H | MEX · Liga MX |
| 21 Apr 2022 |
Atlético de San Luis
|
2–0 | Pumas UNAM | H | MEX · Liga MX |
| 17 Apr 2022 | Pumas UNAM | 2–0 |
|
H | MEX · Liga MX |
| 09 Apr 2022 |
Club Puebla
|
2–2 | Pumas UNAM | D | MEX · Liga MX |
| 03 Apr 2022 |
FC Juárez
|
0–1 | Pumas UNAM | A | MEX · Liga MX |
| 26 Mar 2022 | Pumas UNAM | 1–1 |
|
D | MEX · Liga MX |
| 19 Mar 2022 | Pumas UNAM | 1–3 |
|
A | MEX · Liga MX |
| 13 Mar 2022 |
Cruz Azul
|
2–1 | Pumas UNAM | H | MEX · Liga MX |
| 03 Mar 2022 |
Santos Laguna
|
3–2 | Pumas UNAM | H | MEX · Liga MX |
| 27 Feb 2022 | Pumas UNAM | 0–0 |
|
D | MEX · Liga MX |
| 21 Feb 2022 |
Atlas
|
0–0 | Pumas UNAM | D | MEX · Liga MX |
| 13 Feb 2022 | Pumas UNAM | 2–1 |
|
H | MEX · Liga MX |
| 06 Feb 2022 | Club Tijuana | 1–0 | Pumas UNAM | H | MEX · Liga MX |
| 23 Jan 2022 | Pumas UNAM | 1–2 |
|
A | MEX · Liga MX |
| 15 Jan 2022 |
Querétaro
|
1–3 | Pumas UNAM | A | MEX · Liga MX |
| 11 Jan 2022 | Pumas UNAM | 5–0 |
|
H | MEX · Liga MX |
| 06 Dec 2021 |
Atlas
|
0–1 | Pumas UNAM | A | MEX · Liga MX |
| 03 Dec 2021 | Pumas UNAM | 0–1 |
|
A | MEX · Liga MX |
| 28 Nov 2021 |
Club América
|
1–3 | Pumas UNAM | A | MEX · Liga MX |
| 25 Nov 2021 | Pumas UNAM | 0–0 |
|
D | MEX · Liga MX |
| 21 Nov 2021 |
Deportivo Toluca
|
1–2 | Pumas UNAM | A | MEX · Liga MX |
| 07 Nov 2021 | Pumas UNAM | 4–3 |
|
H | MEX · Liga MX |
| 05 Nov 2021 | Pumas UNAM | 0–3 |
|
A | MEX · Liga MX |
| 31 Oct 2021 |
CF Pachuca
|
1–1 | Pumas UNAM | D | MEX · Liga MX |
| 24 Oct 2021 | Pumas UNAM | 3–1 | Club Tijuana | H | MEX · Liga MX |
| 21 Oct 2021 |
Club León
|
1–2 | Pumas UNAM | A | MEX · Liga MX |
| 17 Oct 2021 | Pumas UNAM | 1–0 |
|
H | MEX · Liga MX |
| 03 Oct 2021 |
Club América
|
2–0 | Pumas UNAM | H | MEX · Liga MX |
| 26 Sep 2021 |
Tigres UANL
|
0–0 | Pumas UNAM | D | MEX · Liga MX |
| 19 Sep 2021 |
Mazatlán
|
2–2 | Pumas UNAM | D | MEX · Liga MX |
| 12 Sep 2021 | Pumas UNAM | 0–0 |
|
D | MEX · Liga MX |
| 29 Aug 2021 |
Deportivo Toluca
|
2–1 | Pumas UNAM | H | MEX · Liga MX |
| 22 Aug 2021 | Pumas UNAM | 2–0 |
|
H | MEX · Liga MX |
| 18 Aug 2021 |
Club Necaxa
|
3–0 | Pumas UNAM | H | MEX · Liga MX |
| 14 Aug 2021 | Pumas UNAM | 0–0 |
|
D | MEX · Liga MX |
| 08 Aug 2021 | Pumas UNAM | 1–3 |
|
A | MEX · Liga MX |
| 01 Aug 2021 |
CF Monterrey
|
2–0 | Pumas UNAM | H | MEX · Liga MX |
| 28 Jul 2021 |
Everton
|
1–0 | Pumas UNAM | H | ITL · Club Friendlies |
| 25 Jul 2021 | Pumas UNAM | 0–0 |
|
D | MEX · Liga MX |